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Asciminib Oral Tablet (ASCIMINIB - ORAL)

For leukemia (CML).

Brand Name(s): Scemblix

Generic Name: Asciminib

Instructions

Swallow the medicine without crushing or chewing it.

Take the medicine without food.

Do not eat for 2 hours before and 1 hour after taking this medicine.

Swallow with a full glass (8 oz) of water unless your doctor gives you different instructions.

This medicine will work best if you take it at about the same time every day.

Store at room temperature away from heat, light, and moisture. Do not keep in the bathroom.

It is important that you keep taking each dose of this medicine on time even if you are feeling well.

If you miss a dose, contact your doctor for instructions.

Drug interactions can change how medicines work or increase risk for side effects. Tell your health care providers about all medicines taken. Include prescription and over-the-counter medicines, vitamins, and herbal medicines. Speak with your doctor or pharmacist before starting or stopping any medicine.

Tell your doctor if symptoms do not get better or if they get worse.

Learn how to check blood pressure at home.

Keep all appointments for medical exams and tests while on this medicine.

Do not take the medicine more than twice during 24 hours.

Cautions

Tell your doctor and pharmacist if you ever had an allergic reaction to a medicine.

Do not use the medication any more than instructed.

This medicine may cause dizziness or fainting. Do not stand or sit up quickly.

If possible, avoid using with alcohol, marijuana, or other medicines that can cause dizziness or drowsiness. These include allergy/cold products, muscle relaxers, sleep aids, and pain relievers.

Your ability to stay alert or to react quickly may be impaired by this medicine. Do not drive or operate machinery until you know how this medicine will affect you.

This medicine may reduce your body's ability to fight infections. Avoid contact with people with colds, flu or other infections. Contact your doctor if you develop fever, cough, sore throat, or chills.

Speak with your health care provider before receiving any vaccinations.

Do not breastfeed while on this medicine. You may safely start breastfeeding 1 week after stopping treatment.

This medicine can hurt a new baby in the womb. If you become pregnant while on this medicine, tell your doctor immediately. Your doctor may switch you to a different medicine.

Women of childbearing age should have a negative pregnancy test before starting this medicine.

Women must use reliable forms of birth control while taking this medicine and for 1 week after stopping to prevent pregnancy.

Women who are pregnant or in their childbearing years should not touch or handle this medicine. This medicine can be absorbed through the woman's skin and harm the unborn baby.

Do not share this medicine with anyone who has not been prescribed this medicine.

Side Effects

The following is a list of some common side effects from this medicine. Please speak with your doctor about what you should do if you experience these or other side effects.

  • blurry vision
  • bone pain
  • diarrhea
  • dizziness
  • lack of energy and tiredness
  • headaches
  • muscle pain
  • nausea and vomiting

Call your doctor or get medical help right away if you notice any of these more serious side effects:

  • bleeding or bruising
  • chest or jaw pain
  • cough that does not go away
  • swelling of the legs, feet, and hands
  • fainting
  • fever or chills
  • fast or irregular heart beats
  • sudden leg pain, swelling, warmth or redness
  • pale or blue skin, lips or fingernails
  • shortness of breath
  • sore throat
  • severe stomach pain that spreads to the back
  • symptoms of stroke (such as one-sided weakness, slurred speech, confusion)
  • excessive or unusual sweating
  • unusual or unexplained tiredness or weakness
  • blurring or changes of vision
  • severe or persistent vomiting
  • sudden or unexplained weight gain

A few people may have an allergic reaction to this medicine. Symptoms can include difficulty breathing, skin rash, itching, swelling, or severe dizziness. If you notice any of these symptoms, seek medical help quickly.

Please speak with your doctor, nurse, or pharmacist if you have any questions about this medicine.